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. 2018 Jul 6;11:231. doi: 10.3389/fnmol.2018.00231

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Copyright © 2018 Xie, Zhou, Wang, Jiang, Cao, Shao, Wang, Li, Shen and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deletion of Lgi1 impairs the differentiation of OPCs. (A) Immunostaining of differentiated OLs (CC1+/Olig2+ cells; inset) in CC of P14 WT and KO mice. Scale bar, 50 μm. Bar graphs show the averages of total Olig2+ cells (p = 0.42; n = 4) and the percentage of CC1+ cells in Olig2+ cells (p = 0.026; n = 6). (B) Immunostaining of platelet-derived growth factor α receptor (PDGFαR) in the CC and cortex of P14 mice. Scale bars, 50 μm. Bar graphs show the averages of total PDGFαR+ cells in CC (p = 0.177; n = 4) and cortex (p = 0.1248; n = 6). (C) Immunostaining of proliferating OLs (Ki67+/Olig2+ cells; indicated by arrows) in the CC of P14 mice. Scale bars, 50 μm. The bar graph shows percentages of Ki67+/Olig2+ cells in total Olig2+ cells (p = 0.1565, n = 4). *p < 0.05, ns, no significance.