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. 2018 Jul 6;9:370. doi: 10.3389/fendo.2018.00370

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Copyright © 2018 Huang, Ma, Chen, Luo, Chen and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction between DNA methylation and transcription factors (TFs). (A) Methylated DNA inhibits the binding of TFs to DNA but also creates binding sites for some specific TFs and activates transcription. (B) Transcriptional repressors occupy an mCpG site, thereby blocking transcription. (C) TFs recruit DNA methyltransferases to form a complex and repress transcription. (D) Methylase acts on TF and regulates its activity and transcription.