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. 2018 Jul 6;9:370. doi: 10.3389/fendo.2018.00370

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Copyright © 2018 Huang, Ma, Chen, Luo, Chen and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction between chromatin remodeling and transcription factors (TFs). (A) Pioneer factors bind to specific DNA sites and form a complex with SWI/SNF to open chromatin. The complex then allows the binding of other TFs, thereby promoting transcription. (B) TFs recruit SWI/SNF to form complexes that lead to chromatin remodeling. (C) Histone variants are inserted into nucleosomes, or nucleosomes are evicted from DNA after histone modification mediated by TFs, ultimately causing chromatin remodeling.