Figure 3.

Analysis of functional hyperemia dynamics and P100 waves during neural tasks. (A and B) Functional hyperemia in the visual cortex (A) and sensorimotor cortex (B) during activation (after an initial 5‐sec period of rapid increase) was fitted using a piecewise (succession of 5‐sec steps) linear mixed‐effects model in 19 patients and 19 controls. Likelihood ratio tests showed a significant difference in the dynamics (slopes) of the response between patients (red) and controls (blue) that was larger at the end phase of the stimulation period for long‐lasting stimulations (**P < 0.01, ***P < 0.001). Changes in functional hyperemia dynamics were mainly detected between 15 and 30 sec (yellow). Dark gray bars represent the difference between mean CBF values measured at different time intervals in control subjects and patients. (C) Average values (solid line) of evoked potentials (shown with their standard deviation, dotted line) obtained after each visual reversal stimulation did not differ between the two groups. (D) Analysis of P100 waves over 5‐sec segments using the piecewise linear mixed‐effects model showed no significant difference over the entire duration of stimulation between the two groups.