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. 2018 May 21;5(7):788–802. doi: 10.1002/acn3.574

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© 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Functional hyperemic responses in the entire population. (A and B) Functional hyperemia in the visual cortex (A) and sensorimotor cortex (B) during activation was fitted in the whole population (29 patients and 29 controls) as was previously done using the piecewise linear mixed‐effects model. Likelihood ratio tests showed a significant difference between the dynamics (slopes) of the response obtained in patients (red) and controls (blue) for long‐lasting stimulations (***P < 0.001). Changes in functional hyperemia dynamics appeared between 15 and 30 sec (yellow). Dark gray bars represent differences between mean CBF values measured at the different time intervals in control subjects and patients. The CBF response analyzed by comparing the slopes between 15 and 30 sec after the stimulus onset using a simple, single‐segment linear‐regression model confirmed the highly significant difference between the 29 patients and 29 controls.