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. 2018 Jul 6;12:194. doi: 10.3389/fncel.2018.00194

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Copyright © 2018 Gárate, Pertusa, Arana and Bernal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanical characterization of PC12 neurites under effects of PFA and Lat-A. (A) The average amplitude fluctuation distribution of the seven plus seven control neurites (N = 14), and the same seven neurites under PFA (N = 7) or Lat-A (N = 7). (B) Average PSD of the Control, PFA and Lat-A PC12 neurites groups. The inset displays the ratio of the averaged altered PSD taking as a reference the average control PSD. (C,D) Quantification of the PFA and Lat-A, respectively, effects in the PC12 neurite mechanical parameters: axial tension σ, plasma membrane tension γ, plasma membrane bending rigidity $K$ .