Table 3.
Logistic regression for dementia risk. Odds ratios [95% CI].
| Model 1 |
Model 2 |
Model 3b |
Model 4c |
|||||
|---|---|---|---|---|---|---|---|---|
| Males | Femalesa | Males | Femalesa | Males | Femalesa | Males | Femalesa | |
|
CONTROL | ||||||||
| control | 0.68* [0.48, 0.97] | 0.92 [0.73, 1.15] | 0.95 [0.61, 1.46] | 0.76 [0.58, 1.00] | 0.81 [0.47, 1.40] | 0.76 [0.55, 1.06] | 0.84 [0.50, 1.39] | 0.86 [0.64, 1.17] |
| apoe | 2.35 [0.98, 5.63] | 1.82* [1.13, 2.95] | 1.56 [0.56, 4.30] | 1.88** [1.16, 3.05] | 1.55 [0.56, 4.29] | 1.88* [1.16, 3.05] | 1.93 [0.68, 5.48] | 1.96** [1.17, 3.26] |
| control*apoe | 0.37* [0.16, 0.85] | 1.88* [1.12, 3.13] | 0.37* [0.16, 0.86] | 1.88* [1.12, 3.13] | 0.39* [0.17, 0.89] | 2.02* [1.15, 3.57] | ||
| constant | 0.09 | 1.10e-06 | 0.10 | 6.60e-07 | 0.07 | 7.10e-07 | 0.07 | 8.37e-07 |
| Pseudo R2 | 0.05 | 0.13 | 0.09 | 0.14 | 0.09 | 0.14 | 0.12 | 0.14 |
| N | 217 | 536 | 217 | 536 | 217 | 536 | 216 | 517 |
| PSYCHOLOGICAL DEMANDS | ||||||||
| dempsych | 0.78 [0.58, 1.05] | 1.12 [0.93, 1.36] | 0.84 [0.56, 1.25] | 1.06 [0.84, 1.34] | – | – | – | – |
| apoe | 2.32 [0.98, 5.53] | 1.83* [1.13, 2.95] | 2.23 [0.93, 5.37] | 1.82* [1.12, 2.94] | – | – | – | – |
| dempsych*apoe | 0.86 [0.48, 1.56] | 1.20 [0.79, 1.82] | – | – | – | – | ||
| constant | 0.09 | 8.23e-07 | 0.10 | 7.96e-07 | – | – | – | – |
| – | – | – | – | |||||
| Pseudo R2 | 0.04 | 0.13 | 0.04 | 0.14 | – | – | – | – |
| N | 217 | 536 | 217 | 536 | – | – | – | – |
| SUPPORT | ||||||||
| support | 0.89 [0.55, 1.44] | 0.96 | 1.16 [0.57, 2.35] | 0.99 | – | – | – | – |
| apoe | 2.08 [0.89, 4.89] | 1.81* | 1.99 [0.82, 4.79] | 1.81* | – | – | – | – |
| support*apoe | 0.53 [0.19, 1.49] | 0.89 | – | – | – | – | ||
| constant | 0.10 | 9.29e-07 | 0.10 | 9.70e-07 | – | – | – | – |
| – | – | – | – | |||||
| Pseudo R2 | 0.02 | 0.13 | 0.03 | 0.13 | – | – | – | – |
| N | 216 | 536 | 216 | 536 | – | – | – | – |
| JOB HAZARDS | ||||||||
| hazards | 1.20 [0.92, 1.57] | 1.22 [0.81, 1.85] | 1.15 [0.80, 1.66] | 1.40 [0.87, 2.27] | – | – | – | – |
| apoe | 2.18 [0.92, 5.14] | 1.81* [1.12, 2.93] | 2.12 [0.89, 5.08] | 1.86* [1.15, 3.01] | – | – | – | – |
| hazards*apoe | 1.09 [0.64, 1.86] | 0.61 [0.25, 1.53] | – | – | – | – | ||
| constant | 0.10 | 1.13e-06 | 0.10 | 9.88e-07 | – | – | – | – |
| – | – | – | – | |||||
| Pseudo R2 | 0.03 | 0.13 | 0.03 | 0.14 | – | – | – | – |
| N | 217 | 536 | 217 | 536 | – | – | – | – |
| PHYSICAL DEMANDS | ||||||||
| demphys | 1.19 [0.96, 1.48] | 1.18 [0.99, 1.39] | 1.18 [0.89, 1.57] | 1.32** [1.07, 1.63] | – | – | – | – |
| apoe | 2.21 [0.93, 5.21] | 1.76* [1.09, 2.85] | 2.19 [0.91, 5.27] | 1.89** [1.16, 3.07] | – | – | – | – |
| demphys*apoe | 1.02 [0.65, 1.59] | 0.72 [0.50, 1.03] | – | – | – | – | ||
| constant | 0.09 | 1.17e-06 | 0.09 | 8.62e-07 | – | – | – | – |
| – | – | – | – | |||||
| Pseudo R2 | 0.03 | 0.14 | 0.03 | 0.14 | – | – | – | – |
| N | 217 | 536 | 217 | 536 | – | – | – | – |
Comment: *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.
a
Adjusted for age (only applicable for women).
b
Adjusted for occupational class.
c
Adjusted for education.