TABLE 1.

GENES MODULATED BY LMP3 IN hMSC

FC*	p-Value†	Probe Set ID	Gene Symbol‡	GenBank ID	Description	GO Biological Process§
↑	0.0001322	203935_at	ACVR1	NM_001105	activin A receptor, type I	G1/S transition of mitotic cell cycle
↓	0.0005144	201924_at	AFF1	NM_005935	AF4/FMR2 family, member 1	positive regulation of transcription
↓	0.0006217	219723_x_at	AGPAT3	NM_020132	l-acylglycerol-3-phosphate O-acyl-transferase 3	metabolic process
↑	0.0009348	20415l_x_at	AKR1C1	NM_001353	aldo-keto reductase family 1, member C1	lipid metabolic process
↑	0.0005113	209699_x_at	AKR1C2	U05598	aldo-keto reductase family 1, member C2	lipid metabolic process
↑	7.97E-05	209160_at	AKR1C3	AB018580	aldo-keto reductase family 1, member C3	prostaglandin metabolic process
↓	0.0004019	209645_s_at	ALDH1B1	NM_000692	aldehyde dehydrogenase 1 family, member B1	carbohydrate metabolic process
↓	0.000398	202686_s_at	AXL	NM_021913	AXL receptor tyrosine kinase	protein amino acid phosphorylation
↑	0.0003068	202705_at	CCNB2	NM_004701	cyclin B2	cell cycle
↑	8.62E-05	209714_s_at	CDKN3	AF213033	cyclin-dependent kinase inhibitor 3	cell cycle
↓	5.32E-05	201445_at	CNN3	NM_001839	calponin 3, acidic	smooth muscle contraction
↓	7.71E-05	203477_at	COL15A1	NM_001855	collagen, type XV, alpha 1	cell adhesion
↓	0.0002589	20255l_s_at	CRIM1	BG546884	cysteine rich transmembrane BMP regulator 1	regulation of cell growth
↓	0.0009697	214377_s_at	CTRL	BF508685	chymotrypsin-like	proteolysis
↓	0.000185	214446_at	ELL2	NM_012081	elongation factor, RNA polymerase II, 2	transcription
↑	0.0004684	204163_at	EMILIN1	NM_007046	elastin microfibril interfacer 1	cell adhesion
↑	3.40E-06	202017_at	EPHX1	NM_000120	epoxide hydrolase 1, microsomal (xenobiotic)	response to toxin
↑	0.0003472	219117_s_at	FKBP11	NM_016594	FK506 binding protein 11, 19 kDa	protein folding
↑	0.0006456	213524_s_at	G0S2	NM_015714	G0/G1 switch 2	cell cycle
↑	0.0005706	204457_s_at	GAS1	NM_002048	growth arrest-specific 1	cell cycle
↓	0.0006808	206432_at	HAS2	NM_005328	hyaluronan synthase 2	—
↑	0.0009572	214022_s_at	IFITM1	AA749101	interferon induced transmembrane protein 1 (9–27)	cell surface receptor linked signal transduction
↑	0.0001397	202409_at	IGF2	X07868	insulin-like growth factor 2 (soma-tomedin A)	skeletal system development
↓	0.0003656	201393_s_at	IGF2R	NM_000876	insulin-like growth factor 2 receptor	transport
↓	0.0009478	201596_x_at	KRT18	NM_000224	keratin 18	apoptosis/cell cycle/morphogenesis
↓	0.0002906	218574_s_at	LMCD1	NM_014583	LIM and cysteine-rich domains 1	negative regulation of transcription
↓	0.0007359	211926_s_at	MYH9	AI827941	myosin, heavy chain 9, non-muscle	cell morphogenesis involved in differentiation
↑	0.0006921	219295_s_at	PCOLCE2	NM_013363	procollagen C-endopeptidase enhancer 2	—
↓	0.000457	20273 l_at	PDCD4	NM_014456	programmed cell death 4	apoptosis/cell cycle/cell aging
↑	0.0004643	217996_at	PHLDA1	NM_007350	pleckstrin homology-like domain, family A, member 1	apoptosis
↓	0.000827	205048_s_at	PSPH	NM_003832	phosphoserine phosphatase	L-serine metabolic process
↑	5.00E-04	218045_x_at	PTMS	NM_002824	parathymosin	DNA replication
↑	0.0003426	203455_s_at	SAT1	NM_002970	spermidine/spermine Nl-acetyltransferase 1	polyamine metabolic process
↓	0.0003915	205396_at	SMAD3	BF971416	SMAD family member 3	negative regulation of transcription
↓	0.0002897	221499_s_at	STX16	AK026970	syntaxin 16	transport
↑	0.0003462	203085_s_at	TGFB1	BC000125	transforming growth factor, beta 1	skeletal system development

^*FC: fold change, arrows indicate the direction of gene modulation.

^† p-Value indicating the significance of differential expression calculated using a t-test with random variance model.

^‡Genes are listed in alphabetical order according to the official gene symbol.

^§GO: gene ontology, primary GO biological process terms are indicated, a — sign stands for missing GO annotations for selected transcripts.