TABLE 2.
GENES MODULATED BY THE ADENOVIRAL BACKBONE IN hMSC
| FC* | Gene Symbol | Gene Title | GenBank ID | Functional Category† |
|---|---|---|---|---|
| ↑ | CCNA2 | cyclin A2 | AI346350 | cell cycle/proliferation/mitosis |
| ↑ | GMNN | geminin, DNA replication inhibitor | NM_015895 | |
| ↑ | CDK2 | cyclin-dependent kinase 2 | M68520 | |
| ↑ | CKS2 | CDC28 protein kinase regulatory subunit 2 | NM_001827 | |
| ↑ | CDC20 | cell division cycle 20 homolog (S. cerevisiae) | NM_001255 | |
| ↑ | CCNB2 | cyclin B2 | NM_004701 | |
| ↑ | MSH2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | U04045 | |
| ↑ | TPX2 | TPX2, microtubule-associated, homolog (Xenopus laevis) | AF098158 | |
| ↑ | AURKA | aurora kinase A | NM_003600 | |
| ↑ | FBXO5 | F-box protein 5 | NM_012177 | |
| ↑ | MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | NM_002358 | |
| ↑ | NUSAP1 | nucleolar and spindle associated protein 1 | NM_016359 | |
| ↑ | SMC4 | structural maintenance of chromosomes 4 | AL136877 | |
| ↑ | ZWINT | ZW10 interactor | NM_007057 | |
| ↑ | PRC1 | protein regulator of cytokinesis 1 | NM_003981 | |
| ↓ | GAS1 | growth arrest-specific 1 | NM_002048 | |
| ↓ | RABGAP1 | RAB GTPase activating protein 1 | AI922519 | |
| ↓ | CCNG1 | cyclin G1 | BC000196 | |
| ↓ | CCL2 | chemokine (C-C motif) ligand 2 | S69738 | |
| ↑ | PTTG1 | pituitary tumor-transforming 1 | NM_004219 | DNA metabolism/replication/recombination |
| ↑ | TK1 | thymidine kinase 1, solubile | NM_003258 | |
| ↑ | TOP2A | topoisomerase (DNA) II alpha 170 kDa | AL561834 | |
| ↑ | FEN1 | flap structure-specific endonuclease 1 | BC000323 | |
| ↑ | PRIM1 | primase, DNA, polypeptide 1 (49 kDa) | NM_000946 | |
| ↑ | CENPA | centromere protein A | NM_001809 | |
| ↑ | MSH6 | mutS homolog 6 (E. coli) | NM_000179 | |
| ↑ | KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | NM_002266 |
*
FC: fold change, arrows indicate the direction of gene modulation.
†
Genes are listed based on their functional category obtained from Gene Ontology annotations.