TABLE 2.

MOST SIGNIFICANTLY AFFECTED GENES

Treatment	Cell Type	Gene Identifier	Log Fold Change	Adjusted Significance
Pravastatin–control	MDA-MB-231	PTGS2*	−2.10	1.62E-11
MβCD–control	MDA-MB-231	Lipocalin-2†	−0.96	6.19E-10
Pravastatin–MβCD	MDA-MB-231	PTGS2	−1.73	6.50E-06
Pravastatin–control	Calu-1	ASNS‡	2.63	5.43E-18
MβCD–control	Calu-1	ASNS	2.87	1.18E-18
Pravastatin–MβCD	Calu-1	RNU1-5§	1.42	1.75E-06

When the 50 genes with the highest fold change are ranked according to adjusted statistical significance these four genes are most impacted.

^*Prostaglindin-endoperoxide synthase-2 is a component of the pathways in cancer and small cell lung cancer pathways.

^†Steroid transport protein.

^‡Asparagine synthetase.

^§snRNA component of the spliceosome.