Table 2.
The relation of miRNAs and target mRNAs with sequence analysis, experimental analysis, and the proposed optimization analysis based on colon cancer.
| mRNA | miRNA | miRandaa | PicTara | PAOMb |
|---|---|---|---|---|
| MAKP14 | miR-141 | O | 8.9 | |
| miR-124 | O | o | 6.6 | |
| CLOCK | miR-30a | O | o | 15.2 |
| miR-17 | O | o | 10.0 | |
| miR-20 | O | o | 5.0 | |
| HMGA2 | miR-30a | O | o | 5.0 |
| THBS1 | miR-155 | O | 7.5 | |
| CXCL12 | miR-124 | O | 6.1 | |
| HRAS | let-7a | O | 8.7 | |
| SIP1 | miR-21 | O | 7.5 | |
| NOTCH1 | miR-155 | O | 5.1 | |
| MTPN | miR-223 | O | o | 5.3 |
| E2F3 | miR-124 | O | 11.1 | |
| SERP1 | miR-223 | O | 12.5 | |
| DVL2 | miR-125a | O | 20.1 |
Abbreviations: mRNA, messenger RNA; miRNA, micro-RNA; PAOM, prediction analysis by optimization method.
a
Predicted targets based on sequence analysis.
b
Predicted targets based on the proposed methods.