Table 1.
Mean ± standard deviation pharmacokinetic parameters of lotilaner in adult cats after either single administration at a target dose of 6 mg/kg orally to fasted cats orally to fed cats, or at a target dose of 3.0 mg/kg intravenously. All values (mean and standard deviation) are based on geometric summary statistics (corresponding to summary statistics of log-transformed values and then back-transformed), except for Tmax which is based on the median
| Parameter | Intravenous, 3 mg/kg (n = 8) |
Oral, fed 6 mg/kg (n = 11) b |
Oral, fasted 6 mg/kg (n = 6) |
|---|---|---|---|
| Actual doses (mg/kg) | 3.07 ± 0.07 | 7.52 ± 0.83 | 8.00 ± 0.70 |
| Tmax (hours) | na | 4 (range: 1–24) | 2 (range: 1–4) |
| Cmax (ng/ml) | na | 3004 ± 709 | 348 ± 249 |
| AUClast (day*ng/ml) | 13,238 ± 2839 | 33,907 ± 6611 | 2901 ± 2207 |
| AUCinf (day*ng/ml) | 23,776 ± 9131 | 68,418 ± 23,220 | 4876 ± 3610 |
| Cmax (dose normalized) (ng/ml)a | na | 403.4 ± 107.0 | 43.6 ± 28.6 |
| AUClast (dose normalized) (day*ng/ml)a | 4315 ± 862 | 4554 ± 762 | 364 ± 255 |
| AUCinf (dose normalized) (day*ng/ml)a | 7750 ± 2876 | 9188 ± 3632 | 612 ± 420 |
| T1/2z (day) | 28.6 ± 14.3 | 33.6 ± 22.0 | 27.1 ± 7.7 |
| MRT (day) | 41.6 ± 19.5 | 48.9 ± 30.7 | 38.6 ± 9.9 |
| CL (l/kg/day) | 0.13 ± 0.05 | na | na |
| Vz (l/kg) | 5.34 ± 1.49 | na | na |
| Vss (l/kg) | 5.37 ± 1.37 | na | na |
| Bioavailability (F%) | na | 106 | 8.4 |
aDose-normalized to 1 mg/kg
aOne cat had an adverse event unrelated to the treatment (leg fracture) and was withdrawn from the study