Table 2.

Comparisons between fed and fasted groups following oral administration of lotilaner at 6 mg/kg

Parameter	Ratio (fasted to fed)	90% CI	t-value	P-valuea
T1/2z	0.806	0.503–1.291	t(22) = -0.79	0.4397
MRT	0.789	0.504–1.234	t(22) = -0.91	0.3730
Cmax (dose normalized)	0.108	0.073–0.159	t(15) = -10.05	< 0.0001
AUClast (dose normalized)	0.080	0.058–0.110	t(22) = -13.44	< 0.0001
AUCinf (dose normalized)	0.067	0.044–0.100	t(22) = -11.33	< 0.0001
Bioavailability	0.080	0.058–0.110	t(22) = -13.44	< 0.0001

^aP-values < 0.0001 denote significance