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. 2018 Jul 13;20:146. doi: 10.1186/s13075-018-1635-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Number of anti-citrullinated protein antibody (ACPA) reactivities according to autoantibody status. a All patients with rheumatoid arthritis (RA). b Controls. c Patients with anti-cyclic citrullinated peptide (anti-CCP)+ RA. d Patients with anti-CCP- RA. e Patients with rheumatoid factor (RF)+ RA. f Patients with RF- RA. g Patients with anti-CCP+/RF+ RA. h Patients with anti-CCP-/RF- RA