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Defective TRPV4-dependent Ca2+ influx in human ADPKD cells. A) Summary graph of averaged changes of [Ca2+]i at baseline and upon the application of the TRPV4 agonist, GSK1016790A (shown with a black bar on the top), in NHK cells (black trace) and ADPKD cells (gray trace). B) Representative pseudocolor images (blue–low and red–high [Ca2+]i) at time point 1 (control) and time point 2 (GSK1016790A) from experiments shown in panel A. Scale bars, 60 µm.
