TABLE 1.
Proteins with significantly increased differential abundance in exosomes collected from asbestos-exposed BEAS2B cells, as compared to exosomes collected from untreated cells
| Accession | Description | Fold Change | P | Adj. P |
|---|---|---|---|---|
| P05121 | Plasminogen activator inhibitor 1 | 1.706 | 4.90E−04 | 1.24E−02 |
| P10643 | Complement component C7 | 1.667 | 1.42E−02 | 5.22E−02 |
| P07437 | Tubulin β chain | 1.666 | 2.68E−02 | 7.19E−02 |
| P68363 | Tubulin α-1B chain | 1.585 | 1.21E−03 | 1.29E−02 |
| P08670 | Vimentin | 1.582 | 1.60E−02 | 5.67E−02 |
| P01031 | Complement C5 | 1.54 | 3.29E−03 | 1.96E−02 |
| P02545 | Prelamin-A/C | 1.515 | 2.54E−04 | 1.24E−02 |
| P05067 | Amyloid β A4 protein | 1.481 | 2.69E−03 | 1.68E−02 |
| P21333 | Filamin-A | 1.466 | 3.89E−04 | 1.24E−02 |
| Q15582 | TGF-β-induced protein ig-h3 | 1.419 | 5.23E−04 | 1.24E−02 |
| P06733 | Alpha-enolase | 1.415 | 9.23E−04 | 1.24E−02 |
| P07355 | Annexin A2 | 1.391 | 3.91E−04 | 1.24E−02 |
| P31947 | 14-3-3 protein sigma | 1.377 | 3.92E−02 | 9.42E−02 |
| Q14767 | Latent-TGF-β- binding protein 2 | 1.371 | 2.16E−03 | 1.60E−02 |
| P62979 | Ubiquitin-40S ribosomal protein S27a | 1.34 | 9.33E−04 | 1.24E−02 |
| P62826 | GTP-binding nuclear protein Ran | 1.334 | 5.89E−03 | 2.98E−02 |
| P55072 | Transitional endoplasmic reticulum ATPase | 1.333 | 5.64E−03 | 2.97E−02 |
| P62937 | Peptidyl-prolyl cis-trans isomerase A | 1.319 | 1.48E−02 | 5.36E−02 |
| P01579 | IFN-γ | 1.315 | 3.38E−02 | 8.60E−02 |
| P60709 | Actin, cytoplasmic 1 | 1.313 | 6.05E−04 | 1.24E−02 |
| Q16270 | IGF-binding protein 7 | 1.308 | 7.28E−04 | 1.24E−02 |
| Q12805 | EGF-containing fibulin-like extracellular matrix protein | 1.306 | 2.50E−03 | 1.68E−02 |
| P00338 | L-lactate dehydrogenase A chain | 1.306 | 2.60E−03 | 1.68E−02 |
| P00736 | Complement C1r subcomponent | 1.295 | 5.37E−03 | 2.87E−02 |
| P07996 | Thrombospondin-1 | 1.292 | 1.43E−02 | 5.24E−02 |
| P11142 | Heat shock cognate 71 kDa protein | 1.285 | 1.46E−03 | 1.35E−02 |
| O43707 | Alpha-actinin-4 | 1.285 | 2.31E−02 | 6.53E−02 |
| Q00610 | Clathrin heavy chain 1 | 1.274 | 2.04E−02 | 6.15E−02 |
| B9A064 | Immunoglobulin λ-like polypeptide 5 | 1.267 | 2.42E−02 | 6.74E−02 |
| P0C0L4 | Complement C4-A | 1.263 | 7.24E−04 | 1.24E−02 |
| P14618 | Pyruvate kinase PKM | 1.263 | 1.84E−02 | 5.95E−02 |
| P68431 | Histone H3.1 | 1.259 | 2.17E−02 | 6.27E−02 |
| P08758 | Annexin A5 | 1.248 | 1.27E−02 | 4.77E−02 |
| Q14624 | Interα-trypsin inhibitor heavy chain H4 | 1.232 | 9.00E−03 | 4.13E−02 |
| P04406 | GAPDH | 1.219 | 1.60E−03 | 1.40E−02 |
| Q15149 | Plectin | 1.215 | 1.41E−05 | 1.70E−03 |
| P35579 | Myosin-9 | 1.211 | 7.55E−03 | 3.69E−02 |
| P68104 | Elongation factor 1-α 1 | 1.207 | 1.05E−02 | 4.38E−02 |
| P39748 | Flap endonuclease 1 | 1.201 | 1.10E−02 | 4.51E−02 |
| O94985 | Calsyntenin-1 | 1.19 | 2.27E−02 | 6.52E−02 |
| P09871 | Complement C1s subcomponent | 1.183 | 1.21E−02 | 4.77E−02 |
| P02675 | Fibrinogen β chain | 1.17 | 5.78E−03 | 2.98E−02 |
| P04075 | Fructose-bisphosphate aldolase A | 1.17 | 1.74E−02 | 5.78E−02 |
| O43854 | EGF-like repeat and discoidin I-like domain- containing protein 3 | 1.168 | 1.42E−02 | 5.22E−02 |
| P35052 | Glypican-1 | 1.163 | 4.18E−03 | 2.33E−02 |
| F8WCM5 | Insulin, isoform 2 | 1.138 | 1.81E−02 | 5.88E−02 |
| P01024 | Complement C3 | 1.135 | 1.82E−03 | 1.52E−02 |
| P21810 | Biglycan | 1.127 | 4.04E−03 | 2.29E−02 |
| Q14980 | Nuclear mitotic apparatus protein 1 | 1.113 | 1.64E−02 | 5.67E−02 |
| Q9UBX5 | Fibulin-5 | 1.102 | 1.90E−02 | 5.97E−02 |
| P49747 | Cartilage oligomeric matrix protein | 1.056 | 1.69E−02 | 5.72E−02 |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was identified as differentially expressed in the asbestos-exposed group with identified tryptic peptides sharing no sequence identity with those from yeast GAPDH, which was added as a control.