TABLE 2.
PCR array analysis showing top 10 up- and down-regulated genes in HPM3 cells exposed to asbestos-treated BEAS2B exosomes
| Gene name | Fold change | P |
|---|---|---|
| Up-regulated | ||
| Six transmembrane epithelial antigen of the prostate 1 | 1.298 | 1.83E−02 |
| Zinc finger E-box binding homeobox 1 | 1.2646 | 7.25E−01 |
| Versican | 1.198 | 1.54E−01 |
| Vacuolar protein sorting 13 homolog A (S. cerevisiae) | 1.1452 | 1.40E−01 |
| Calcium/calmodulin-dependent protein kinase II inhibitor 1 | 1.1322 | 2.91E−01 |
| Notch 1 | 1.1207 | 6.04E−01 |
| Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1.1198 | 3.16E−01 |
| Tetraspanin 13 | 1.1198 | 1.97E−01 |
| PTK2 protein tyrosine kinase 2 | 1.1171 | 1.50E−01 |
| Pleckstrin 2 | 1.1126 | 1.89E−01 |
| Down-regulated | ||
| Matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 0.5824 | 3.05E−01 |
| Fibroblast growth factor binding protein 1 | 0.6299 | 6.80E−02 |
| Cadherin 1, type 1, E-cadherin (epithelial) | 0.6597 | 4.86E−02* |
| Desmocollin 2 | 0.7248 | 1.03E−01 |
| IL-1 receptor antagonist | 0.7297 | 3.25E−02* |
| Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 0.746 | 7.46E−02 |
| Desmoplakin | 0.7474 | 8.24E−03* |
| SRY (sex determining region Y)-box 10 | 0.7577 | 9.83E−02 |
| Bone morphogenetic protein 7 | 0.7594 | 1.02E−01 |
| Goosecoid homeobox | 0.7594 | 1.02E−01 |
*
P ≤ 0.05.