TABLE 4.
Microarray analysis showing top 10 up- and down-regulated genes in HPM3 cells exposed to asbestos administered THP-1 exosomes as compared to control exosomes
| Gene name | Fold change | P |
|---|---|---|
| Up-regulated | ||
| EGR1 | 3.43 | 9.60E−03 |
| Meiosis-specific nuclear structural 1 | 3.22 | 3.10E−03 |
| Histone cluster 1, H3g | 2.82 | 3.00E−05 |
| Transcript identified by AceView, Entrez Gene ID 4731 | 2.81 | 1.00E−03 |
| POTE ankyrin domain family, member C | 2.69 | 3.40E−03 |
| Long intergenic non-protein coding RNA 663 | 2.54 | 7.50E−03 |
| PARP1 binding protein | 2.53 | 9.00E−03 |
| Fanconi anemia complementation group D2 | 2.47 | 2.40E−02 |
| Transcript identified by AceView, Entrez Gene IDs 79677 | 2.42 | 1.48E−02 |
| Chromosome 16 open reading frame 52 | 2.34 | 4.02E−02 |
| Down-regulated | ||
| CRELD2 | 0.156 | 1.30E−03 |
| Glycoprotein Ib (platelet), β polypeptide; septin 5 | 0.225 | 1.78E−02 |
| Stromal cell-derived factor 2-like 1 | 0.271 | 7.30E−03 |
| ERO1β | 0.285 | 5.00E−04 |
| Schlafen family member 11 | 0.314 | 5.00E−03 |
| JAG1 | 0.321 | 2.00E−04 |
| Arginase 2 | 0.344 | 3.25E−02 |
| Cell division cycle 6 | 0.351 | 9.10E−03 |
| Transcript identified by AceView, Entrez Gene IDs 153339 | 0.365 | 1.88E−02 |
| GTPase, IMAP family member 2 | 0.373 | 1.58E−02 |