TABLE 5.
Microarray analysis showing top 10 up- and down-regulated genes in HPM3 cells exposed to asbestos administered THP-1 exosomes as compared to asbestos fiber exposure
| Gene name | Fold change | P |
|---|---|---|
| Up-regulated | ||
| Somatomedin B and thrombospondin type 1 domain containing | 86.62 | 3.16E−12 |
| RAB7B, member RAS oncogene family | 39.61 | 3.05E−09 |
| Family with sequence similarity 198, member B | 34.44 | 5.99E−11 |
| Wingless-type MMTV integration site family, member 2B | 34.16 | 4.45E−11 |
| Aldo-keto reductase family 1, member B15 | 24.6 | 4.64E−09 |
| SMAD family member 6 | 23.55 | 3.04E−09 |
| Aldo-keto reductase family 1, member B10 (aldose reductase) | 20.27 | 2.29E−08 |
| Tetraspanin 8 | 19.43 | 2.25E−07 |
| Matrix-remodelling–associated 5 | 19.4 | 3.84E−11 |
| Calbindin 2 | 18.92 | 1.35E−11 |
| Down-regulated | ||
| Lipocalin 2 | 0.003 | 1.30E−12 |
| IL-24 | 0.016 | 1.43E−12 |
| Endothelial cell-specific molecule 1 | 0.017 | 2.31E−12 |
| Paired related homeobox 1 | 0.018 | 3.66E−09 |
| Hyaluronan synthase 2 | 0.018 | 5.89E−09 |
| Proplatelet basic protein | 0.030 | 1.75E−10 |
| IL-36, β | 0.042 | 3.21E−09 |
| Family with sequence similarity 129, member A | 0.049 | 3.06E−10 |
| Keratin associated protein 21-2 | 0.051 | 1.37E−09 |
| Activating transcription factor 3 | 0.052 | 5.73E−09 |