Fig. 1.

CASC15 expression is increased in melanoma tumor tissues and correlated with melanoma development. a CASC15 expression in melanoma tissues (n = 461) and normal tissues (n = 558) was analyzed by GEPIA tool (http://gepia.cancer-pku.cn/detail.php?gene=&clicktag=boxplot). b CASC15 expression in different pathological stages of melanoma from GEPIA database. Relative expression levels of CASC15 in melanoma tissues (n = 42) and adjacent non-cancerous tissues (n = 42) (c), different clinical pathological stages (stage I (n = 11), stage II (n = 17), stage III (n = 14) (d), primary (n = 24) and metastatic melanoma tissues (n = 18) (e). f CASC15 expression in melanoma cells (A375, SK-MEL-2, M21, MEL-RM, B16 and SK-MEL-1) and normal human epidermal melanocytes (HEMa-LP). Results are represented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001