Fig. 4.

Family pedigree. Numbers above symbols represent year of birth and death, when available. Types of malignancies are listed below symbols and ages of diagnoses are indicated in parentheses, when available. Arrow indicates the proband; red symbols indicate individuals who were tested and found to be carriers of the BAP1 mutation; green symbols indicate individuals who were tested and found carrying wildtype BAP1 gene; D year of death, MM mesothelioma, ccRCC renal cell carcinoma, all other cancer types are indicated by their full name or anatomical location; “unknown”, the cause of death was cancer, but the histological type was not identified. “no cancer”, the cause of death was not cancer; A-07 was not tested for the presence of the BAP1 mutation, however he is an obligate carrier