Table 3.
Performance of LM, RDT and LAMP for diagnosing malaria in peripheral blood samples
| Test | Value (95% CI) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| nPCRa | Sensitivity | Specificity | PPV | NPV | Kappa | ||||
| (+) | (−) | Total | |||||||
| LM | |||||||||
| (+) | 31 | 0 | 31 | 79.5% (64.5–89.2) | 100.0% (99.2–100.0) | 100.0% (89.0–100.0) | 98.4% (96.9–99.2) | 0.9 (0.8–1.0) | |
| (−) | 8 | 492 | 500 | ||||||
| RDT | |||||||||
| (+) | 30 | 0 | 30 | 76.9% (61.7–87.4) | 100.0% (99.2–100.0) | 100.0% (88.6–100.0) | 98.2% (96.6–99.1) | 0.9 (0.8–1.0) | |
| (−) | 9 | 492 | 501 | ||||||
| LAMP | |||||||||
| (+) | 39 | 0 | 39 | 100.0% (92.4–100.0) | 100.0% (99.2–100.0) | 100.0% (92.0–100.0) | 100.0% (99.2–100.0) | 1.00 (1.0–1.0) | |
| (−) | 0 | 492 | 492 | ||||||
LM: light microscopy; RDT: rapid diagnostic test; LAMP: loop-mediated isothermal amplification; nPCR: nested polymerase chain reaction; (+): positive; (−): negative; PPV: positive predictive value; NPV: negative predictive value; CI: confidence interval
anPCR was used as the reference test