Table 1.

Scoring system for identification of histologic lesions by H&E staining

Score	Definition
0a	None
1b	Focal granulomatous inflammation (lamina propria or subcortical sinus, cortex only)
2c	Multifocal to coalescing granulomatous inflammation (lamina propria or subcortical sinus or cortex only)
3	Coalescing/diffuse granulomatous inflammation (lamina propria, subcortical sinus, cortex)
4d	Coalescing/diffuse granulomatous inflammation (extending into submucosa or medulla)
5	Coalescing/diffuse lesions extending deeply into submucosa ± lymphangitis

^a Scores of 0 were classified as within normal limits.

^b Scores of 1 were classified as mild lesions.

^c Scores of 2–3 were classified as moderate lesions.

^d Scores of 4–5 were classified as severe lesions.