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. 2018 Jul 12;15:204. doi: 10.1186/s12974-018-1240-3

Table 2.

Canonical pathways

Brain
 Pattern 1
  Pancreatic adenocarcinoma signaling
  Role of CHK proteins in cell cycle checkpoint control
  T helper cell differentiation
  Cyclins and cell cycle regulation
  Th1 pathway
  Bladder cancer signaling
  Inhibition of angiogenesis by TSP1
  Dopamine receptor signaling
  ILK signaling
  B cell development
  Cell cycle regulation by BTG family proteins
  Inhibition of matrix metalloproteases
  Thyroid cancer signaling
  HIF1α signaling
  Crosstalk between dendritic cells and natural killer cells
  Th1 and Th2 activation pathway
  Role of JAK family kinases in IL-6-type cytokine signaling
  Role of JAK1 and JAK3 in γc cytokine signaling
  Role of Oct4 in mammalian embryonic stem cell pluripotency
  Autoimmune thyroid disease signaling
Spleen
 Pattern 1  Pattern − 1
  Heme biosynthesis II   cAMP-mediated signaling
  Mitotic roles of polo-like kinase   G-Protein coupled receptor signaling
  Heme biosynthesis from uroporphyrinogen-III I   Serine biosynthesis
  Tetrapyrrole biosynthesis II   Superpathway of serine and glycine biosynthesis I
  Estrogen-mediated S-phase entry   LPS/IL-1-mediated inhibition of RXR function
  GADD45 signaling   Protein kinase A signaling
  Cell cycle: G2/M DNA damage checkpoint regulation   Cardiac hypertrophy signaling
  Cyclins and cell cycle regulation   Fatty acid activation
  dTMP de novo biosynthesis   nNOS signaling in skeletal muscle cells
  Cell cycle control of chromosomal replication   Corticotropin releasing hormone signaling
  DNA damage-induced 14-3-3σ signaling
  Rapoport-Luebering glycolytic shunt
  Pyrimidine deoxyribonucleotides de novo biosynthesis I
  ATM signaling
  Antiproliferative role of TOB in T cell signaling
  Role of CHK proteins in cell cycle checkpoint control
  Cell cycle: G1/S checkpoint regulation
  Cell cycle regulation by BTG family proteins
  Asparagine biosynthesis I
  γ-Glutamyl cycle