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. 2018 Jul 13;37:149. doi: 10.1186/s13046-018-0831-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — STAT3 elevated LINC01287 expression via c-jun. a The putative transcription factor-binding sites of c-jun in the LINC01287 promoter region. b Western blot revealed that STAT3 positively regulated c-jun expression. c Knockdown of c-jun decreased the expression of miR-298 in both Huh7 and Bel7402 cells. d An up-regulation of wild-type miR-298 promoter luciferase activity was observed upon up-regulation of c-jun in Huh cells. e When c-jun binding sites on LINC01287 were mutated, the effect of c-jun on LINC01287 in Huh7 cells was abolished. f In si-STAT3 cells, the forced overexpression of c-jun increased LINC01287 expression. g In HCC cells in which STAT3 was overexpressed, the knockdown of c-jun decreased LINC01287 expression. h LINC01287 expression was positively correlated with STAT3 expression in HCC