Table 5.
Diagnostic values of FNA, CNB, and combined FNA/CNB for thyroid malignancy in nodules with a final diagnosis
| Diagnostic values | All (n=686) |
FNA/CNB | P-value |
|||
|---|---|---|---|---|---|---|
| FNA | CNB | FNA vs. CNB | FNA vs. FNA/CNB | CNB vs. FNA/CNB | ||
| Criterion 1: category VI | ||||||
| Sensitivity | 175/281 (62.3) | 251/281 (89.3) | 256/281 (91.1) | <0.001 | <0.001 | 0.063 |
| Specificity | 405/405 (100) | 405/405 (100) | 405/405 (100) | NA | NA | NA |
| PPV | 175/175 (100) | 251/251 (100) | 256/256 (100) | NA | NA | NA |
| NPV | 405/511 (79.3) | 405/435 (93.1) | 405/430 (94.2) | >0.999 | >0.999 | >0.999 |
| Accuracy | 580/686 (84.5) | 656/686 (95.6) | 661/686 (96.4) | <0.001 | <0.001 | 0.063 |
| Criterion 2: categories IV, V, VI | ||||||
| Sensitivity | 239/281 (85.1) | 274/281 (97.5) | 275/281 (97.9) | <0.001 | <0.001 | 0.500 |
| Specificity | 403/405 (99.5) | 400/405 (98.8) | 400/405 (98.8) | 0.250 | 0.250 | >0.999 |
| PPV | 239/241 (99.2) | 274/279 (98.2) | 275/280 (98.2) | >0.999 | >0.999 | >0.999 |
| NPV | 403/445 (90.6) | 400/407 (98.3) | 400/406 (98.5) | >0.999 | >0.999 | >0.999 |
| Accuracy | 642/686 (93.6) | 674/686 (98.3) | 676/686 (98.5) | <0.001 | <0.001 | 0.500 |
Values are presented as number (%).
FNA, fine-needle aspiration; CNB, core needle biopsy; NA, not applicable; PPV, positive predictive value; NPV, negative predictive value.