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Small-cell neuroendocrine carcinoma of the gallbladder. Histopathological examination of the gallbladder specimen reveals involvement of all layers of the gallbladder wall and focal tumor necrosis (A, B). On Immunohistochemistry, CD 56 shows diffuse positive membranous staining (C) and Ki 67 shows a high proliferation rate with almost 100% staining (D).
