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. Author manuscript; available in PMC: 2019 Apr 24.
Published in final edited form as: Cell Rep. 2018 Apr 24;23(4):1192–1204. doi: 10.1016/j.celrep.2018.03.112

Figure 7. Mechanisms Underlying Trimeric LUBAC Stabilization.

Figure 7.

HOIL-1L and SHARPIN gather on the HOIP UBA via rapid interactions between HOIP UBA and UB. During this process, the LTMs of both proteins heterodimerize to form the TD. Peptidebased LTM inhibitor destabilizes LUBAC by blocking TD formation.