Table 2.
Genetic models of imprinted expression and DNA methylation regulators at the Igf2r locus in mice.
| Genotype | Tissue | Allelic expression | Igf2r ICR DNA methylation | Reference |
|---|---|---|---|---|
| Dnmt1n/n(hypomorph) | E10.5 embryos | Igf2r = | *Igf2r ↓ | [18] |
| Dnmt1s/s (replication foci targeting domain mutation) | E9.5 embryos | Igf2r repressed | ND | |
| Dnmtn/c(c = null) | E9.5 embryos | Igf2r repressed | Igf2r ↓ | |
| Dnmt3amat–/−;Dnmt3b+/− | E9.5 embryos | ND | Igf2r ↓ | [112] |
| Dnmt3a2lox/1lox, TNAP–Cre × WT male (maternal deletion only) | E10.5 embryos | Igf2r repressed | Igf2r ↓ | [113] |
| Dnmt3l−/− | ESCs | ND | Igf2r = | [112] |
| Dnmt3lmat–/− | E9.5 embryos | ND | Igf2r ↓ | |
| Zfp57mat–/− (maternal-zygotic) | E11.5-E13.5 embryos | ND | * Igf2r ↓ | [76] |
| Zfp57−/− (zygotic null) | E11.5-E13.5 embryos | ND | * Igf2r ↓ | |
| Zfp57+/− | Oocytes | ND | * Igf2r ↓ | |
| Zfp57−/− | Oocytes | ND | * Igf2r ↓ | |
| Trim28chatwo/chatwo (zygotic hypomorph) | E8.5 embryos | * Airn biallelic | ND | [82] |
| Trim28mat–/+(maternal null) | 8-cell stage embryos | ND | * Igf2r ↓ | [83] |
| Tet1Gt/Gt (catalytic domain removed) | E9.5 embryos | * Airn repressed | * Igf2r ↑ | [96] |
Table Key: *(partially penetrant); ND (no data); = (no change); ↓ (hypomethylated); ↑ (hypermethylated); # (age not explicitly stated) P (postnatal day); PN (pronuclear stage); ESCs (embryonic stem cells); PGCs (primordial germ cells).