Table 3.

Univariate and multivariate analysis of factors associated with recurrence-free survival

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age	0.929 (0.525–1.644)	0.801
Sex	1.346 (0.758–2.389)	0.311
Tumor location	0.823 (0.465–1.456)	0.504
Tumor differentiation	0.998 (0.614–1.625)	0.995
T stage	2.259 (1.013–5.036)	0.046	2.168 (0.970–4.842)	0.059
Regional lymph node metastasis	3.657 (1.820–7.348)	<0.001	1.969 (0.905–4.284)	0.088
Distant metastasis	5.606 (3.010–10.439)	<0.001	2.770 (1.398–5.489)	0.003
Tumor size	0.599 (0.338–1.059)	0.078
High SPINT1-AS1 expression	4.355 (2.219–8.549)	<0.001	2.519 (1.180–5.378)	0.017

Abbreviations: SPINT1-AS1, serine peptidase inhibitor, Kunitz type 1 antisense RNA1; HR, hazard ratio; CI, confidence interval.