Table 1.
Effects of ovarian progesterone (P4) and intrauterine infusion of IFNT or prostaglandins (PGs) on elongation- and implantation-related genes expressed in the endometrial epithelia of the ovine uterus.1
| Gene symbol and general function | P4 | IFNT |
|---|---|---|
| Transporters of glucose | ||
| SLC2A1 | ↑ | + |
| SLC2A5 | n.d. | n.e. |
| SLC2A12 | n.d. | + |
| SLC5A1 | ↑ | + |
| SLC5A11 | ↑ | + |
| Transporters of amino acids | ||
| SLC1A5 | n.d. | n.d. |
| SLC7A2 | ↑ | + |
| Cell proliferation, migration, attachment | ||
| GRP | ↑ | + |
| IGFBP1 | ↑ | + |
| LGALS15 | ↑ | ++ |
| SPP1 | ↑ | + |
| Proteases and their inhibitors | ||
| CTSL1 | ↑ | ++ |
| CST3 | ↑ | + |
| CST6 | ↑ | + |
| Intracellular enzymes | ||
| HSD11B1 | ↑ | + |
| PTGS2 | ↑ | n.e.2 |
| Transcription factors | ||
| HIF1A | ↑ | + |
| HIF2A | ↑ | + |
1Effect of hormone or factor denoted as induction (↑), stimulation (+), no effect (n.e.), decrease (−), or not determined (n.d.).
2No effect (n.e.) on gene expression, but increases PTGS2 activity.
SLC2A1, Solute carrier family 2, facilitated glucose transporter member 1; SLC2A5, Solute carrier family 2, facilitated glucose transporter member 5; SLC2A12, Solute carrier family 2, facilitated glucose transporter member 12; SLC1A5, Solute carrier family 5, facilitated glucose transporter member 5; SLC5A11, Solute carrier family 2, facilitated glucose transporter member 11; SLC1A5, Neutral amino acid transporter B(0); SLC7A2, Low affinity cationic amino acid transporter 2; GRP, gastrin releasing peptide; IGFBP1, insulin-like growth factor binding protein 1; LGALS15, galectin 15; SPP1, secreted phosphoprotein 1; CTSL1, cathepsin L; CST3, cystatin 3; CST6, cystatin 6; HSD11B1, hydroxysteroid 11-beta dehydrogenase type 1; PTGS2, prostaglandin synthase 2; HIF1A, hypoxia inducible factor 1 alpha; HIF2A, hypoxia inducible factor 2 alpha.