Table 3.

Prognostic factors in the Cox proportional hazards model

Variables	OS
	HR	Univariate 95% CI	Sig	HR	Multivariate 95% CI	Sig
Gender
Male vs female	1.232	0.528–1.312	0.782
Age
<50 vs ≥50	0.982	0.785–2.201	0.936
Smoking
No vs yes	2.723	1.823–4.192	0.021	3.556	2.238–3.984	0.152
pT
T1–2 vs T3–4	3.112	2.230–4.762	0.002*	5.397	3.343–7.842	0.0001*
Histology
Squamous vs adenocarcinoma	1.274	0.542–2.723	0.803
TNM stage
I–II vs III–IV	1.682	0.926–2.698	0.437
Differentiation
Low vs moderate-high	2.091	1.134–2.803	0.182
LNM
− vs +	1.892	1.117–2.437	0.235
CDR1as expression
Low vs high	3.583	1.668–4.826	0.006*	6.132	2.923–7.556	0.0001*

Note:

^*P < 0.05.

Abbreviations: CI, confidence interval; HR, hazard ratio; LNM, lymph node metastasis; OS, overall survival.