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. 2018 Jun 26;9(49):29162–29179. doi: 10.18632/oncotarget.25646

Figure 6. Bacteroidetes, B. uniformis and C. perfringens are significantly enriched in N14-77 intestinal microbiota.

Figure 6

(A) Bacteroidetes is the dominating phylum. The pie charts indicate the composition of bacterial phyla, determined by searching WGS reads against microbial genome databases HMP and ABG. (B) Bacteriotecea is the dominant family in polyps. The colors represent bacterial phyla as shown in A. (C) B. uniformis and C. perfringens are among the top enriched species. (D) ATCC 8492 is the most enriched strain of B. uniformis (left), determined with WGS reads, and expresses abundantly thioredoxin and nitroreductase genes (right), determined with RNA-seq reads. (E) N14-77 polyps resemble invasive tumors, but not proliferative tumors, in redox gene expression. The images indicate sample clustering based on the ssGSEA enrichment scores with indicated gene sets. (F) C. perfringens strain enrichment and toxin gene expression.