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. 2018 Jun 26;9(49):29047–29063. doi: 10.18632/oncotarget.25540

Figure 2. TNFα stimulation of OSCC cells promotes up-regulation of gene clusters associated with neutrophil recruitment, invasion, and invadopodia.

Figure 2

(A) Classification of up-regulated and down-regulated genes identified by mRNA sequencing, based on their GeneCards and UniProt identified function. Overlap of known neutrophil-related genes (genes which products can recruit/activate neutrophils) (B), invadopodia (C), and invasion (D) up-regulated genes and cell-cycle (E) down-regulated genes identified by mRNA sequencing. The lists of genes were overlaid using Cytoscape, and the combined list of common nodes was used to build a physical and functional map association in STRING (grey lines). The results are based on three independent experiments in which 500,000 UMSCC1 cells were stimulated with TNFα (10 ng/mL) followed by lysis and RNA extraction.