Figure 1. Gene Set Enrichment Analysis (GSEA) in recurrent glioma.

GSEA of differential expression between recurrent and initial high-grade glioma demonstrates that recurrent GBM is enriched in genes that participate in the p53 tumor suppressor pathway (A), heme metabolism (B) and interferon signaling (C–D). ES–enrichment score, NES–normalized enrichment score, FDR–false discovery ratio.