. 2018 Jun 26;9(49):29238–29258. doi: 10.18632/oncotarget.25579

Table 1. Most significant eQTLs for significant intergenic SNPs in AOs GWAs.

SNP from GWAS (Supplementary Table 1)	Gene	Near gene (cited in the GWAs)	Most significant eQTLs (GTEx project)	p-value (GTEx project)	Tissue
rs10871454	STX4	VKORC1	KAT8	1.1e-38	Skin^a
rs10871454	STX4	VKORC1	VKORC1	1.5e-30	Liver^b
rs9923231		VKORC1	KAT8	1.2e-38	Skin^a
rs9923231		VKORC1	VKORC1	2.0e-33	Liver^b
rs12777823		CYP2C18	CYP2C19	6.9e-31	Esophagus - Mucosa
rs12777823		CYP2C18	MTND4P19	3.5e-14	Skin
rs2104162		CYP2C9	CYP2C19	1.1e-10	Esophagus- Mucosa
rs2104162		CYP2C9	MTDN4P19	0.0000069	Esophagus- Mucosa
rs749671	ZNF646	VKORC1	KAT8	1.9e-39	Skin^a
rs749671	ZNF646	VKORC1	VKORC1	3.0e-32	Liver^b
rs4918798		CYP2C9	C10orf129	1.2e-12	Adipose - Subcutaneous
rs4918798		CYP2C9	CYP2C8	0.000077	Breast - Mammary Tissue
rs17126068		DDHD1	RP11-547D23.1	1.4e-9	Testis
rs17126068		DDHD1	DDHD1	7.0e-7	Muscle - Skeletal
rs889548	MYST1	VKORC1	KAT8	7.1e-43	Skin
rs889548	MYST1	VKORC1	VKORC1	1.2e-30	Liver^b
rs1978487	MYST1	VKORC1	KAT8	1.1e-39	Skin^a
rs1978487	MYST1	VKORC1	VKORC1	7.0e-26	Liver^b
rs749767	BCKDK	VKORC1	KAT8	5.7e-40	Skin^a
rs749767	BCKDK	VKORC1	VKORC1	3.9e-27	Liver^b
rs3862009		CYP2C19	C10orf129	1.7e-40	Adipose-subcutaneous^a
rs3862009		CYP2C19	CYP2C9	7.2e-9	Adipose-subcutaneous
rs12610189		CYP4F2	AC004791.2	1.3e-40	Lung^a,b
rs12610189		CYP4F2	CYP4F2	9.3e-11	Skin
rs1998591		CYP2C18	CYP2C19	1.1e-17	Esophagus - Mucosa
rs1998591		CYP2C18	C10orf129	4.1e-10	Nerve - Tibial^a
rs2104543		CYP2C18	CYP2C19	1.1e-15	Esophagus - Mucosa
rs2104543		CYP2C18	C10orf129	3.8e-10	Nerve - Tibial^a
rs12772169		CYP2C18	CYP2C19	2.1e-17	Esophagus - Mucosa
rs12772169		CYP2C18	C10orf129	3.1e-10	Esophagus - Mucosa^a
rs11150604	ZNF646	VKORC1	KAT8	1.1e-38	Skin^a
rs11150604	ZNF646	VKORC1	VKORC1	1.5e-30	Liver^b
rs1980889		CKS2	SEMA4D	1.3e-7	Thyroid
rs1980889		CKS2	CKS2	0.0000091	Liver
rs746357		SHC3	SEMA4D	1.3e-7	Thyroid
rs746357		SHC3	CKS2	0.0000091	Liver

Enumeration of the most significant eQTLs for SNPs associated with AOs response located in 1) intragenic regions attributed to regulate other genes in the referenced paper; 2-intergenic regions. Column one: SNP ID (from Supplementary Table 1); Column two: gene, for intragenic SNPs; Column three: near gene described in the original GWAs to be the effector gene; Column four: most significant eQTLs from GTEx project. P-value indicated for the most significant eQTL in the gene; Column five: p-values for the most significant eQTL for each gene; Column six: tissues where the most significant eQTLs are expressed.

^a Significant eQTL also in arteries (p<10-5); ^b Significant eQTL also in whole blood (p<10-5).

eQTL= expression quantitative trait loci; GTEx project= Genotype-Tissue Expression project.