Table 2.
Regulatory sequences demonstrated to drive Cre expression in mouse trophoblast cell lineages.
| Regulatory sequencea | Cellular target(s) | References |
|---|---|---|
| Cyp19a1 | All trophoblast lineages first detectable in extraembryonic ectoderm and ectoplacental cone structures | 146 |
| Chimeric Tpbpa/Ada enhancer | All trophoblast lineages | 151 |
| Krt5 | All trophoblast lineages first detectable in the ectoplacental cone; visceral yolk sac | 152 |
| Tpbpa | Trophoblast progenitors in the ectoplacental cone that give rise to subsets of trophoblast giant cells, spongiotrophoblast, glycogen trophoblast cells | 148 |
| Prdm1 | Trophoblast progenitors in the junctional zone, spongiotrophoblast, subsets of trophoblast giant cells, and glycogen trophoblast cells | 149 |
| Prl3d1 | Trophoblast giant cells | 150 |
| Prl2c2 | Trophoblast giant cells | 150 |
| Prl3b1 | Placenta (specific cell types were not reported; would expect trophoblast giant cell expression) | 153 |
| Ctsq | Trophoblast giant cells of the labyrinth zone and lining channels in the junctional zone | 155 |
| Gcm1 | Syncytiotrophoblast layer-II | 147, 154 |
aAll regulatory sequences are from the mouse except for human Cyp19a1.