Table 3.
Tumor Tissue Genomic Profiles (n=15 patients)*
| Patient | Primary Cancer | Tissue DNA Alterations1 | ctDNA Alterations1 | |
|---|---|---|---|---|
| Not in ctDNA Panel | In ctDNA Panel | |||
| 1 | Colon |
KRAS, APC, PIK3CA |
KRAS, NOTCH, TP53 |
|
| 2 | Appendix | GNAS | GNAS | |
| 3 | Colon | PIK3R1 |
TP53 APC, KRAS |
TP53 RIT1 (not in tissue panel) |
| 4 | Appendix | GNAS | ||
| 5 | Appendix | RBM10 |
KRAS,
SMAD4, TP53 |
|
| 6 | Small Bowel | CHEK2 | KRAS | |
| 7 | Appendix | SMAD2 | KRAS | |
| 8 | Appendix |
MAP2K4,
SPTA1, TGFBR2 |
GNAS,
KRAS |
|
| 9 | Appendix | TGFBR2 |
GNAS,
KRAS, PIK3CA |
|
| 10 | Appendix |
KRAS,
SMAD4, TP53 |
||
| 11 | Appendix | TGFBR2 |
GNAS,
KRAS |
|
| 12 | Colon | AKT3, BARD1, FGF23, FGF6, KDM5A, KDM6A, |
CCND2,
KRAS, MYC |
CCND2, KRAS, MET, MYC |
| 13 | Appendix | TGFBR2 |
GNAS,
KRAS |
|
| 14 | Colon | BTG1, CARD11, CREBBP, FAM123B, PIK3R2, PMS2, SOX9, TGFBR2 |
APC, KRAS, TP53 |
APC, KRAS |
| 15 | Bile Duct |
CDKN2A,
KRAS, MTOR, TP53 |
||
*
Tissue NGS was performed at Foundation Medicine based on tissue obtained at the time of index surgery. ctDNA was generally obtained within two weeks prior to surgery.
1
Include characterized alterations and VUS