Table 4.
Univariate and Multivariate Predictors of PFS (by Cox Proportional Hazards Model)*.
| Variable | Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|---|
| Median PFS (months) (95% CI) | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Preoperative ctDNA Alterations % cfDNA1 | |||||
| < 0.25% (n=55) | 15.0 (11.8, 18.3) | 3.23 (1.43, 7.28) | 0.005 | 2.36 (1.02, 5.45) | 0.044 |
| ≥ 0.25% (n=25) | 7.8 (3.6, 12.0) | ||||
| Complete Resection | |||||
| Yes (n=33) | 14.5 (10.3, 18.8) | 0.96 (0.65, 1.41) | 0.837 | ||
| No (n=47) | 13.4 (6.5, 20.4) | ||||
| Grade2 | |||||
| Low (n=36) | Not reached | 1.99 (1.29, 3.09) | 0.002 | 3.30 (1.34, 8.11) | 0.009 |
| High (n=39) | 9.6 (7.1, 12.1) | ||||
*
Multivariate model was developed using variables that were significant (P < 0.05) in univariate analysis. All HRs are given for ≥ 0.25% vs. < 0.25 peak % cfDNA, No vs. Yes Complete Resection, and High vs. Low Grade, respectively
1
ctDNA as highest % of altered circulating cell-free DNA (peak % cfDNA)
2
Excluding patients with mesothelioma
Abbreviations: cfDNA = cell free DNA; CI = confidence interval; HR = hazard ratio; PFS = progression-free survival