Table 3.

A comparison of K^trans values in different patient disease categories across different research groups. The missing values were not reported in the studies reviewed.

Groups	Study	Disease	Patients Ktrans (×10−3 min−1)
			NAWM	WM	GM	WMH
Backes	(van de Haar et al., 2017)	early AD	0.075±0.046		0.104±0.124
	(Zhang et al., 2017)	cSVD	0.97±0.04		1.43±0.05(CGM) 1.06±0.04(DGM)	0.85±0.03
	(van de Haar et al., 2016a)	early AD	0.065±0.043	0.066±0.04	0.089±0.11	0.106±0.11
	(Wong et al., 2017)	cSVD		1.3±0.5	2.2±0.7
	(van de Haar et al., 2016b)	early AD			0.27±0.14
Wardlaw	(Munoz Maniega et al., 2017)	Mild stroke	0.224±0.37			0.350±0.48
	(Heye et al., 2016)	Mild stroke	0.296±0.01		0.391±0.012 (DGM)	0.396±0.013
Zlokovic	(Montagne et al., 2015)	MCI		2.30±0.36	0.89±0.24*
		MS		2.53±0.27	0.80±0.16*
Rosenberg	(Taheri et al., 2011a)	SIVD				3±2
		MI/LAC				2.5±1
	(Taheri et al., 2011b)	VCI		2.4±0.5
		MS		2.3±0.5

^*, denotes thalamus regions

cSVD, Cerebral Small Vessel Disease; AD, Alzheimer’s Disease; VCI, Vascular Cognitive Impairment; MCI, Mild Cognitive Impairment; MS, Multiple Sclerosis; WMH, White Matter Hyperintensities; WM, White Matter; GM, Gray Matter; NAWM, Normal Appearing White Matter; SIVD, Subcortical Ischemic Vascular Disease; MI/LAC, Multiple and Lacunar infarcts