Table 5.

Effect sizes calculated for the studies reported on comparing K^trans values between controls and patients across different research groups.

$$\mathbf{\text{Effect Size}}=\frac{{\mu }_{\mathit{\text{patient}}}-{\mu }_{\mathit{\text{control}}}}{s_{\mathit{\text{pooled}}}}$$

Groups	Study	Disease	Sample Size		Effect Size
			Patients	Controls	WM	GM
Backes	(van de Haar et al., 2017)	early AD	16	17	0.09314	0.9404(CGM)
	(Zhang et al., 2017)	cSVD	77	39	−1.83533	−1.04447(CGM) −1.05021(DGM)
	(van de Haar et al., 2016a)	early AD	16	17	−0.07796	0.75237
	(van de Haar et al., 2016b)	early AD	14	16	NA	−0.66798
Zlokovic	(Montagne et al., 2015)	MCI	21	18	0.37743	0.37961(Thalamus)
Rosenberg	(Taheri et al., 2011a)	SIVD	36	17	0.89268	NA
		MI/LAC	17	17	1.26491	NA
	(Taheri et al., 2011b)	VCI	45	20	1.40878	NA

WM, White Matter; GM, Gray Matter; CGM, Cortical Gray Matter; DGM, Deep Gray Matter; cSVD, Cerebral Small Vessel Disease; AD, Alzheimer’s Disease; VCI, Vascular Cognitive Impairment; MCI, Mild Cognitive Impairment; SIVD, Subcortical Ischemic Vascular Disease; MI/LAC, Multiple and Lacunar infarcts

NA – Effect sizes not calculated as corresponding K^trans values were not reported in the studies reviewed