Table 3 (a).

Diagnostic performance of four markers in detecting AFP-positive or AFP-negative patients with HCC

Marker	HCC vs LC+CHB+HC		HCC vs LC+CHB		HCC vs LC
	AUC (95% CI)a	SEN at 90% SPE (95% CI)b	AUC (95% CI)a	SEN at 90% SPE (95% CI)b	AUC (95% CI)a	SEN at 90% SPE (95% CI)b
AFP-positivec
AFP-L3	0.95 (0.89–0.99)	89.4 (82.6–100.0)	0.93 (0.90–0.98)	85.1 (70.0–100.0)	0.93 (0.91–0.99)	87.9 (71.4–100.0)
DCP	0.84 (0.63–0.85)	65.4 (61.4–88.9)	0.82 (0.62–0.84)	64.5 (59.5–87.9)	0.78 (0.63–0.84)	59.3 (50.0–83.3)
SCCA	0.46 (0.36–0.61)	7.8 (0–21.4)	0.45 (0.31–0.62)	8.4 (0–29.4)	0.45 (0.31–0.62)	8.4 (0–29.4)
CENPF	0.65 (0.62–0.81)	21.7 (5.9–47.6)	0.53 (0.40–0.71)	11.7 (0–29.2)	0.53 (0.40–0.71)	11.7 (0–29.2)
AFP-negativec
AFP-L3	0.48 (0.46–0.53)	6.7 (0–11.5)	0.46 (0.44–0.52)	7.2 (0–10.3)	0.46 (0.44–0.52)	7.0 (0–10.7)
DCP	0.78 (0.62–0.81)	56.3 (48.4–77.8)	0.76 (0.61–0.82)	56.6 (48.1–75.8)	0.73 (0.61–0.81)	52.1 (41.4–72.5)
SCCA	0.47 (0.36–0.59)	6.8 (0–27.3)	0.47 (0.34–0.63)	7.8 (0–38.1)	0.47 (0.34–0.63)	7.8 (0–38.1)
CENPF	0.60 (0.55–0.77)	20.0 (6.7–41.2)	0.50 (0.38–0.67)	12.5 (0–31.6)	0.50 (0.38–0.67)	12.5 (0–31.6)