Table 4(a).

Diagnostic performance of marker combinations in detecting HCC

Marker	HCC vs LC+CHB +HC		HCC vs LC+CHB		HCC vs LC
	AUC (95% CI)a	SEN at 90% SPE (95% CI)b	AUC (95% CI)a	SEN at 90% SPE (95% CI)b	AUC (95% CI)a	SEN at 90% SPE (95% CI)b
AFP+AFP-L3	0.69 (0.65–0.78)	46.5 (35.2–57.7)	0.66 (0.63–0.76)	40.9 (30.8–53.7)	0.66 (0.63–0.77)	43.4 (30.8–55.3)
AFP+DCP	0.87 (0.68–0.84)	73.8 (63.6–84.2)	0.84 (0.67–0.83)	68.2 (59.4–78.5)	0.83 (0.68–0.84)	64.2 (53.9–76.6)
AFP-L3+DCP	0.84 (0.64–0.83)	71.0 (60.4–83.3)	0.82 (0.62–0.82)	66.3 (54.5–77.8)	0.81 (0.63–0.83)	63.7 (52.8–77.8)
AFP+AFP-L3+DCP	0.85 (0.64–0.84)	73.7 (60.8–85.1)	0.83 (0.63–0.83)	65.7 (54.7–78.6)	0.81 (0.64–0.84)	64.5 (52.8–78.7)