(b).
Diagnostic performance of marker combinations in detecting early-stage HCC
| Marker | Early-stage HCC vs LC+CHB+HC
|
Early-stage HCC vs LC +CHB
|
Early-stage HCC vs LC
|
|||
|---|---|---|---|---|---|---|
| AUC (95% CI)a | SEN at 90% SPE (95% CI)b | AUC (95% CI)a | SEN at 90% SPE (95% CI)b | AUC (95% CI)a | SEN at 90% SPE (95% CI)b | |
| AFP+AFP-L3 | 0.58 (0.49–0.69) | 26.8 (10.0–42.9) | 0.56 (0.46–0.68) | 25.0 (9.5–41.7) | 0.56 (0.45–0.68) | 25.7 (7.7–42.1) |
| AFP+DCP | 0.79 (0.73–0.88) | 59.8 (46.4–77.4) | 0.77 (0.71–0.86) | 56.0 (43.2–70.6) | 0.75 (0.71–0.87) | 52.6 (37.0–68.6) |
| AFP-L3+DCP | 0.72 (0.64–0.84) | 47.9 (33.3–72.2) | 0.69 (0.61–0.83) | 42.9 (25.0–64.3) | 0.67 (0.61–0.83) | 42.5 (22.2–63.7) |
| AFP+AFP-L3+DCP | 0.72 (0.61–0.85) | 49.7 (34.8–73.3) | 0.70 (0.58–0.83) | 45.3 (25.0–64.3) | 0.68 (0.59–0.83) | 42.7 (23.1–64.7) |
Note:
a
AUC was adjusted for potential overfitting by the .632+ bootstrap method.
b
.632+ bootstrap adjusted sensitivity at cutoffs yielding 90% specificity.
Abbreviations: AFP, alpha-fetoprotein; AFP-L3, lens culinaris agglutinin-reactive AFP; AUC, area under the curve; CHB, chronic hepatitis B virus infection; DCP, des-gamma-carboxyprothrombin; HC, healthy control; HCC, hepatocellular carcinoma; LC, liver cirrhosis; SEN, sensitivity; SPE, specificity.