Table 3. Multivariate analysis on OS and PFS.

Characteristics	OS			PFS
	P	HR	95% CI	P	HR	95% CI
Age (≤65/>65)	0.049	1.497	1.002–2.235	0.120	1.289	0.922–1.803
Male	0.027	1.620	1.057–2.481	0.059	1.385	0.988–1.941
Histology (adenocarcinoma/squamous cell)	0.766	1.092	0.610–1.955	0.693	1.108	0.665–1.847
Hemoglobin, g/dL (<13/≥13)	0.317	1.245	0.810–1.914
Albumin, g/dL (<3.1/≥3.1)	0.035	1.724	1.039–2.861	0.091	1.478	0.939–2.326
CRP, mg/dL (<2.68/≥2.68)	0.011	1.713	1.130–2.599	0.138	1.289	0.922–1.803
COP-LMR (0,1,2)	0.009			0.025
COP-LMR 0	-	1	Referent	-	1	Referent
COP-LMR 1	0.021	1.822	1.096–3.027	0.116	1.347	0.929–1.951
COP-LMR 2	0.003	2.464	1.373–4.421	0.007	1.902	1.194–3.028

CI: confidence interval; COP-LMR: combination of platelet and lymphocyte to monocyte ratio; CRP: c-reactive protein; HR: hazard ratio; OS: overall survival; PFS: progression free survival.