Table 2. Mutagenic Activity of CK-1δ Inhibitor 4 Using S. typhimurium Strains, without S9 Activation, Scored at Day 5.
| TA100
strain |
TA98
strain |
||||
|---|---|---|---|---|---|
| compound | number positive wells/total number of wells | resultsa | compound | number positive wells/total number of wells | resultsa |
| background (TA100) | 3/96 | background (TA98) | 21/96 | ||
| background (TA100) | 7/96 | background (TA98) | 26/96 | ||
| blank | 0/96 | blank | 0/96 | ||
| control (NaN3) | 74/96 | + | control (2-NF) | 95/96 | + |
| 4 (20 μM) | 1/96 | – | |||
| 4 (1 μM) | 8/96 | – | 4 (10 μM) | 9/96 | – |
| 4 (0.5 μM) | 5/96 | – | |||
a
+, Significant increase in the number of positive wells compared with the related control; −, no significant effect observed.