Table 4. IC₅₀ Data for the Disruption of Cbx7–Compound 1 Complex by Inhibitors with Both N-Terminal and N-Alkyl Substitutions on the Scaffold 2^a.

^aBinding data determined from the inhibitor concentration needed to half-dissociate the Cbx7–compound 1 complex. Data are the averages of two or three independent experimental trails and expressed as IC₅₀ ± standard error in μM. FP data obtained upon titrating varied concentrations of inhibitors into a fixed concentration of Cbx protein. Buffer and concentrations of compound 1, and Cbx protein concentrations are as reported in Table 2.