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Top-ranked compounds. Shown are the top three compounds for Tc- (left) and TcMCS-based (right) rankings according to Figure 4 using (a) cabozantinib, (b) iloperidone, (c) tolvaptan, and (d) sorafenib as reference drugs. Compounds whose ranks are highlighted in green are active against the drug target. For each of the top three compounds, the rank using the alternative similarity measure (Tc, right; TcMCS, left) is also reported (in italics).
