Chart 5. Basic regimen for the treatment of tuberculous meningitis in children.

Treatment phase	Drugsa	Daily dosage, by patient weight
		≤ 20 kg	21-25 kg	26-30 kg	31-35 kg	36-40 kg	41-45 kg	≥ 45 kg
		mg/kg	mg	mg	mg	mg	mg	mg
2RHZ	Rifampin	15 (10-20)	300	450	500	600	600	600
	Isoniazid	10 (7-15)	200	300	300	300	300	300
	Pyrazinamide	35 (30-40)	750	1000	1000	1500	1500	2000
10RH	Rifampin	15 (10-20)	300	450	500	600	600	600
	Isoniazid	10 (7-15)	200	300	300	300	300	300

Source: World Health Organization.^{(17) a}During the treatment of tuberculous meningitis, a corticosteroid can be added to the anti-tuberculosis regimen: oral prednisone (1-2 mg/kg daily) for four weeks or, in severe cases, intravenous dexamethasone (0.3-0.4 mg/kg daily) for 4-8 weeks, with gradual dose reductions over the subsequent 4 weeks.