Chart 6. Factors to consider when choosing the treatment regimen for children with multidrug-resistant tuberculosis.

• Confirmed susceptibility to or presumed efficacy of all drugs of the short MDR-TB regimen (isoniazid resistance excepted) • No exposure to the second-line MDR-TB regimen for > 1 month • No intolerance to any drug in the short non-toxic MDR-TB regimen (i.e., drug interactions) • Pregnancy excluded • Pulmonary disease only • All drugs in the short MDR-TB regimen are available for the program
↓ YES ↓			↓ NO ↓
Short MDR-TB regimen	Regimen failure, drug intolerance, return after interruption for > 2 months, emergence of an exclusion criterion →		Longer (individualized) MDR-TB regimen

MDR-TB: multidrug-resistant tuberculosis. Source: Grzemska M.⁽⁹⁾